Is sublingual immunotherapy applicable to food allergies?

1. Research situation overseas

2. Expanding possibilities through practical application

3. Introduction and research progress in Japan

Sublingual immunotherapy ( SLIT ) is widely known as a treatment for allergic rhinitis and asthma, but in recent years, its application to food allergies has also been attracting attention . Below, we will provide a detailed explanation of the current state of research into SLIT overseas, the expanding possibilities of its practical application, and the progress of its introduction and research in Japan.

1. Research situation overseas

Research into SLIT for food allergies such as peanuts and milk is currently underway, mainly in Europe and the United States . These studies have reported that administering a small amount of allergen sublingually can reduce allergic reactions by inducing immune tolerance. For example, a certain degree of effectiveness has been confirmed in clinical trials of SLIT for patients with peanut allergies .

2. Expanding possibilities through practical application

If SLIT for food allergies becomes practical, the following possibilities are expected:

Improved quality of life: Food allergy sufferers must constantly be aware of dietary restrictions and the risk of ingesting food accidentally in their daily lives. If SLIT could reduce allergic reactions, this burden could be alleviated and quality of life could be improved .

• Increased social security: There is a need for greater understanding and support for food allergies in schools, workplaces, etc. The widespread use of SLIT is expected to increase the sense of security in society as a whole .

3. Introduction and research progress in Japan

Research into SLIT for food allergies is also underway in Japan. For example, research at Miyazaki University has reported that SLIT is effective in preventing allergic asthma, food allergies, and systemic anaphylaxis. ( Miyazaki University ) However, at present, SLIT for food allergies is not covered by insurance and has not yet been put to practical use in clinical trials. It is hoped that future research findings and progress in clinical trials will lead to its practical application.

Sublingual immunotherapy for food allergies has the potential to significantly improve the quality of life of patients. Future research and clinical applications are attracting attention.